Cutaneous hyperpigmentation and cobalamin deficiency

Reversible cutaneous hyperpigmentation in vitamin B12 deficiency.

Received: 08.02.2013; Revised: 01.04.2013; Accepted: 26.04.2013 A 6 6 ye a r o l d m a l e p r e s e n t e d w i t h g e n e r a l i s e d we a k n e s s , hyperpigmentation of knuckles and decreased appetite since two months. Clinical examination revealed a bald tongue, pallor, glossitis, stomatitis, k n u c k l e p i g m e n t a t i o n , p a l m pigmentation, pigmentation of the sole (Figure...

Cobalamin deficiency, hyperhomocysteinemia, and dementia

INTRODUCTION Although consensus guidelines recommend checking serum B12 in patients with dementia, clinicians are often faced with various questions: (1) Which patients should be tested? (2) What test should be ordered? (3) How are inferences made from such testing? (4) In addition to serum B12, should other tests be ordered? (5) Is B12 deficiency compatible with dementia of the Alzheimer's typ...

Diagnosis of cobalamin deficiency.

Helicobacter pylori and cobalamin deficiency.

We have read with interest Maktouf et al.’s letter about the etiological role of deficiencies of cobalamin or folate in megaloblastic anemia. In this large prospective series, they investigated 478 patients with megaloblastic changes in bone marrow smears and reported the demographic, biological and clinical findings in cobalamin-deficient patients and patients with pernicious anemia. Out of 43...

Leukemia cutis presenting as localized cutaneous hyperpigmentation.

The usual clinical presentations of leukemia cutis include solitary infiltrated erythematous or violaceous plaques or nodules and multiple localized or generalized papules. On the other hand, cutaneous hyperpigmentation is a frequent finding in patients with malignancies, most of the cases because of chemotherapy or other drugs that the patient is taking. We present a case of cutaneous hyperpig...